The live recording of "Read My Mind" on the Late Show with David Letterman showcased The Killers at a pivotal moment in their career during the promotion of their third studio album, "Sam's Town," released in 2006. This album marked a significant shift for the band, moving from the synth-driven sound of their earlier works to a more Americana-influenced rock style. The performance reflects the band's growing confidence and their efforts to forge a unique identity in the post-punk revival scene of the mid-2000s. Interestingly, "Read My Mind" became one of the album's standout tracks, further solidifying their status in the music world, and the live appearance on a prominent platform like Letterman emphasized their rising popularity. It was during this era that The Killers began to cultivate their image as a band deeply connected to the American landscape and its themes, which would continue to evolve in future projects.