In the live performance of "Family Tree" on Letterman, Kings of Leon showcased their evolving sound as they transitioned into a more mainstream appeal during the release of their fifth studio album, "Come Around Sundown," which was launched in October 2010. By the time of this performance in 2010, the band had already achieved significant commercial success with their earlier albums, particularly "Only by the Night," which featured major hits like "Use Somebody" and "Sex on Fire." "Family Tree," with its rootsy, Southern rock vibe, reflects the band's expansion of their musical range. Notably, this performance highlights how Kings of Leon embraced their Southern heritage while continuing to captivate a global audience, reinforcing their status as one of the standout bands of the 2000s. Their appearance on "Letterman" also marked a critical moment for further establishing their presence in popular music culture.