On January 10, 2011, The Black Keys performed "Howlin' For You" on the Late Show with David Letterman, which was a pivotal moment in their career. This performance came shortly after the release of their album "Brothers," which debuted in May 2010 and marked a significant breakthrough for the duo. "Brothers" showcased their blues-infused rock sound and included hit singles such as "Tighten Up" alongside "Howlin' For You." The album won three Grammy Awards, helping to elevate their profile in the music industry. The performance on Letterman highlighted their growing popularity, as they transitioned from indie favorites to mainstream rock stars. Interestingly, "Howlin' For You" became a staple in their setlist and featured in various media, further solidifying their impact on contemporary rock music during this period.